Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial

Eur J Clin Nutr. 2008 Apr;62(4):570-4. doi: 10.1038/sj.ejcn.1602724. Epub 2007 Mar 21.


Objectives: To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.

Design: Placebo-controlled, crossover, randomized trial.

Setting: Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona).

Subjects: Twenty-eight stable coronary heart disease patients.

Interventions: A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.

Results: Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.

Conclusions: Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antioxidants / administration & dosage*
  • Antioxidants / metabolism
  • C-Reactive Protein / metabolism*
  • Coronary Disease / blood
  • Coronary Disease / diet therapy*
  • Cross-Over Studies
  • Dietary Fats, Unsaturated / administration & dosage*
  • Dietary Fats, Unsaturated / metabolism
  • Double-Blind Method
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Lipid Metabolism / drug effects
  • Male
  • Olive Oil
  • Plant Oils* / chemistry


  • Antioxidants
  • Dietary Fats, Unsaturated
  • Interleukin-6
  • Olive Oil
  • Plant Oils
  • C-Reactive Protein