A real-time measure of cavitation induced tissue disruption by ultrasound imaging backscatter reduction

IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar;54(3):569-75. doi: 10.1109/tuffc.2007.279.


A feedback method for obtaining real-time information on the mechanical disruption of tissue through ultrasound cavitation is presented. This method is based on a substantial reduction in ultrasound imaging backscatter from the target volume as the tissue structure is broken down. Ex-vivo samples of porcine liver were exposed to successive high-intensity ultrasound pulses at a low duty cycle to induce mechanical disruption of tissue parenchyma through cavitation (referred to as histotripsy). At the conclusion of treatment, B-scan imaging backscatter was observed to have decreased by 22.4 +/- 2.3 dB in the target location. Treated samples of tissue were found to contain disrupted tissue corresponding to the imaged hypoechoic volume with no remaining discernable structure and a sharp boundary. The observed, substantial backscatter reduction may be an effective feedback mechanism for assessing treatment efficacy in ultrasound surgery using pulsed ultrasound to create cavitation.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Computer Systems
  • Image Interpretation, Computer-Assisted / methods*
  • In Vitro Techniques
  • Liver / diagnostic imaging*
  • Liver / surgery*
  • Radiation Dosage
  • Radiometry / methods
  • Scattering, Radiation
  • Surgery, Computer-Assisted / methods*
  • Swine
  • Ultrasonic Therapy / methods*
  • Ultrasonography / methods*