Exercise and colon cancer: primary and secondary prevention

Curr Sports Med Rep. 2007 Apr;6(2):120-4. doi: 10.1007/BF02941153.


Many studies have demonstrated the effects of exercise on both primary and secondary prevention of colon cancer. Exercise appears to have a dose-response reduction in the rate of colon cancer. The mechanism by which exercise provides this benefit is not known, but increase in insulin-like growth factor-binding protein and reduction of prostaglandins appear to be the likely cause. Once a person develops colon cancer the benefits of exercise appear to continue both by increasing quality of life and reducing cancer-specific and overall mortality.

Publication types

  • Review

MeSH terms

  • Colonic Neoplasms / epidemiology*
  • Colonic Neoplasms / prevention & control*
  • Exercise Therapy / methods*
  • Exercise Therapy / statistics & numerical data*
  • Humans
  • Incidence
  • Physical Fitness*
  • Primary Prevention / methods*
  • Risk Reduction Behavior*
  • Treatment Outcome
  • United States