Triggering antiviral response by RIG-I-related RNA helicases

Biochimie. 2007 Jun-Jul;89(6-7):754-60. doi: 10.1016/j.biochi.2007.01.013. Epub 2007 Feb 20.

Abstract

TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use*
  • Cytoplasm / enzymology
  • Cytoplasm / metabolism
  • Humans
  • Immunity, Innate
  • Membrane Proteins / chemistry
  • Models, Biological
  • Nerve Tissue Proteins / chemistry
  • Protein Structure, Tertiary
  • RNA Helicases / chemistry*
  • RNA, Double-Stranded / chemistry*
  • RNA, Viral / chemistry
  • Receptors, Cell Surface
  • Signal Transduction
  • Toll-Like Receptors / metabolism

Substances

  • Antiviral Agents
  • Membrane Proteins
  • Nerve Tissue Proteins
  • RNA, Double-Stranded
  • RNA, Viral
  • Receptors, Cell Surface
  • Robo3 protein, mouse
  • Toll-Like Receptors
  • RNA Helicases