Influenza has been, and continues to be, a serious threat to human life. The 1918 influenza pandemic infected nearly one quarter of the world's population and resulted in the deaths of 100 million people. Most of the countries in the world were heavily impacted. What happened in China during this period? Compared with other countries, the severity of infection in China was relatively mild. Did traditional Chinese medicine (TCM) play any role, either in the prevention or treatment of the epidemics? This paper explores the situation in China at that particular time.