p53 in Health and Disease

Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83. doi: 10.1038/nrm2147.

Abstract

As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism. Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Cycle / physiology
  • DNA Damage / physiology
  • Health Status*
  • Humans
  • Models, Biological
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / physiopathology*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Protein p53 / physiology*

Substances

  • Tumor Suppressor Protein p53