A study of possible correlation between subarachnoid haemorrhage related vasospasm and the post-bleed blood platelet count chart in a Caucasian population

Acta Neurochir (Wien). 2007;149(4):387-91. doi: 10.1007/s00701-007-1124-2. Epub 2007 Mar 28.

Abstract

Introduction: There has been controversy about the aetiology and pathophysiology of subarachnoid haemorrhage (SAH) related vasospasm. Several pathogenic factors like endothelin and adhesion molecules have been discussed. A recently published study concerning an exclusively Asian population suggested a relationship between SAH related vasospasm and the blood platelet count. The aim of our study was to examine this relationship in a European population.

Method: We carefully reviewed 88 patients with aneurysmal SAH (54 females, 34 males; mean age 52.5 years, range from 22 to 78 years) treated in our centre with regard to the occurrence of vasospasm and the blood platelet count in a ten day interval after initial SAH. Symptomatic vasospasm was defined as a focal neurological deficit or deterioration in the level of consciousness with or without confirmation of infarction on a CT scan. Thirty-seven patients (42%) developed clinically relevant vasospasm.

Results: There was no statistically significant correlation between the blood platelet count chart (maximum and minimum values) and vasospasm or clinical outcome; we also found no gender or age-related influence on the above mentioned relationships.

Conclusions: In our opinion there appears to be a difference between Caucasian and Asian populations regarding the influence of platelets in the pathophysiology of SAH and vasospasm.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Asians
  • Blood Coagulation / physiology
  • Blood Platelets / physiology
  • Brain Infarction / etiology
  • Brain Infarction / physiopathology
  • Female
  • Humans
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / physiopathology
  • Male
  • Middle Aged
  • Platelet Count
  • Sex Factors
  • Subarachnoid Hemorrhage / blood
  • Subarachnoid Hemorrhage / complications*
  • Subarachnoid Hemorrhage / physiopathology*
  • Vasospasm, Intracranial / blood
  • Vasospasm, Intracranial / etiology*
  • Vasospasm, Intracranial / physiopathology*
  • Whites