Transfer of dexamphetamine into breast milk during treatment for attention deficit hyperactivity disorder

Br J Clin Pharmacol. 2007 Mar;63(3):371-5. doi: 10.1111/j.1365-2125.2006.02767.x. Epub 2006 Sep 12.


Aims: To investigate dexamphetamine transfer into milk, infant doses and effects in the breast-fed infant.

Methods: Four women taking dexamphetamine, and their infants were studied.

Results: The median maternal dexamphetamine dose was 18 mg day(-1) (range 15-45 mg day(-1)). Median (interquartile range) descriptors were 3.3 (2.2-4.8) for milk/plasma ratio, 21 microg kg(-1) day(-1) (11-39) for absolute infant dose and 5.7% (4-10.6%) for relative infant dose. No adverse effects were seen. In three infants tested, dexamphetamine in plasma was undetected in one (limit of detection 1 microg l(-1)) and present at 18 microg l(-1) and 2 microg l(-1) in the other two.

Conclusion: Dexamphetamine readily transfers into milk. The relative infant dose was <10% and within a range that is generally accepted as being 'safe' in the short term.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Breast Feeding*
  • Dextroamphetamine / adverse effects*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Milk, Human / chemistry*
  • Pregnancy


  • Dextroamphetamine