Hereditary demyelinating neuropathy in the trembler mouse

J Neurol Sci. 1975 Dec;26(4):565-74. doi: 10.1016/0022-510x(75)90057-x.


The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.

MeSH terms

  • Action Potentials
  • Animals
  • Chromosome Aberrations
  • Chromosome Disorders
  • Demyelinating Diseases / pathology*
  • Demyelinating Diseases / physiopathology
  • Demyelinating Diseases / veterinary
  • Mice*
  • Muscles / physiopathology
  • Neural Conduction
  • Peripheral Nerves / pathology*
  • Peripheral Nerves / physiopathology
  • Peripheral Nervous System Diseases / pathology*
  • Peripheral Nervous System Diseases / physiopathology
  • Peripheral Nervous System Diseases / veterinary
  • Reaction Time