Role of growth factors on periodontal repair

Growth Factors. 2006 Dec;24(4):260-7. doi: 10.1080/08977190601060990.


Regeneration of periodontal structures lost during periodontal diseases constitutes a complex biological process regulated among others by interactions between cells and growth factors. Growth factors are biologically active polypeptides affecting the proliferation, chemotaxis and differentiation of cells from epithelium, bone and connective tissue. They express their action by binding to specific cell-surface receptors present on various target cells including osteoblasts, cementoblasts and periodontal ligament fibroblasts. The observation that growth factors participate in all cell functions led to exogenous application during periodontal tissue repair aiming to their use as an alternative therapeutic approach to periodontal therapy. Cell types and cultures conditions, dose, carrier materials, application requirements are of critical importance in the outcome of periodontal repair. The purpose of this article is to review the literature with respect to the biological actions of PDGF, TGF, FGF, IGF and EGF on periodontal cells and tissues, which are involved in periodontal regeneration.

Publication types

  • Review

MeSH terms

  • Alveolar Bone Loss / therapy*
  • Animals
  • Bone Regeneration*
  • Epidermal Growth Factor / pharmacology
  • Epidermal Growth Factor / physiology
  • Epidermal Growth Factor / therapeutic use
  • Fibroblast Growth Factors / pharmacology
  • Fibroblast Growth Factors / therapeutic use
  • Humans
  • Intercellular Signaling Peptides and Proteins* / pharmacology
  • Intercellular Signaling Peptides and Proteins* / physiology
  • Intercellular Signaling Peptides and Proteins* / therapeutic use
  • Platelet-Derived Growth Factor / pharmacology
  • Platelet-Derived Growth Factor / physiology
  • Platelet-Derived Growth Factor / therapeutic use
  • Rats
  • Somatomedins / pharmacology
  • Somatomedins / physiology
  • Somatomedins / therapeutic use
  • Transforming Growth Factor beta / pharmacology
  • Transforming Growth Factor beta / physiology
  • Transforming Growth Factor beta / therapeutic use


  • Intercellular Signaling Peptides and Proteins
  • Platelet-Derived Growth Factor
  • Somatomedins
  • Transforming Growth Factor beta
  • Fibroblast Growth Factors
  • Epidermal Growth Factor