Neutrophilic dermatosis resembling pyoderma gangrenosum in a dog with polyarthritis

J Small Anim Pract. 2007 Apr;48(4):229-32. doi: 10.1111/j.1748-5827.2006.00209.x.

Abstract

This report describes a case of neutrophilic dermatosis in a dog, with a number of clinical and pathological similarities to human pyoderma gangrenosum. A seven-year-old, female German shepherd dog with a history of non-erosive idiopathic polyarthritis was presented with severe facial swelling, bilateral erosivoulcerative lesions on the muzzle and multiple, eroded, dermal-subcutaneous nodules on the cranial trunk. Histopathological examination of skin biopsies revealed a necrotising neutrophilic dermatitis. No infectious agents could be detected using specific stains, immunohistochemistry, serology and bacterial aerobic, anaerobic or fungal cultures. A sterile neutrophilic dermatosis resembling human pyoderma gangrenosum was presumptively diagnosed, and the patient showed an excellent response to treatment with prednisone and ciclosporin.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Arthritis / complications
  • Arthritis / veterinary
  • Cyclosporine / therapeutic use
  • Dermatologic Agents / therapeutic use*
  • Diagnosis, Differential
  • Dog Diseases / diagnosis*
  • Dog Diseases / drug therapy
  • Dog Diseases / pathology
  • Dogs
  • Female
  • Prednisone / therapeutic use
  • Pyoderma Gangrenosum / diagnosis
  • Pyoderma Gangrenosum / drug therapy
  • Pyoderma Gangrenosum / pathology
  • Pyoderma Gangrenosum / veterinary
  • Sweet Syndrome / diagnosis
  • Sweet Syndrome / drug therapy
  • Sweet Syndrome / pathology
  • Sweet Syndrome / veterinary*
  • Treatment Outcome

Substances

  • Dermatologic Agents
  • Cyclosporine
  • Prednisone