Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis

Neurobiol Aging. 2008 Aug;29(8):1279-82. doi: 10.1016/j.neurobiolaging.2007.02.022. Epub 2007 Mar 23.


There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / epidemiology*
  • Amyotrophic Lateral Sclerosis / genetics*
  • Case-Control Studies
  • Cytoskeletal Proteins / genetics*
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Incidence
  • Intercellular Signaling Peptides and Proteins / genetics*
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Prevalence
  • Progranulins
  • Risk Assessment / methods*
  • Risk Factors
  • United Kingdom / epidemiology


  • Cytoskeletal Proteins
  • GRN protein, human
  • IFT74 protein, human
  • Intercellular Signaling Peptides and Proteins
  • Progranulins