Abstract
The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / metabolism
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism*
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Burkholderia pseudomallei / genetics
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Burkholderia pseudomallei / metabolism*
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Burkholderia pseudomallei / physiology
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Chromatography, High Pressure Liquid
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Gene Expression Regulation, Bacterial
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Homoserine / analogs & derivatives
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Homoserine / metabolism
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Lactones / metabolism
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Mutation
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Quorum Sensing / genetics
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Quorum Sensing / physiology*
Substances
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Bacterial Outer Membrane Proteins
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Lactones
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N-octanoylhomoserine lactone
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homoserine lactone
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Homoserine
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4-Butyrolactone