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, 14 (4), 349-50

The 3' Termini of Mouse Piwi-interacting RNAs Are 2'-O-methylated

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The 3' Termini of Mouse Piwi-interacting RNAs Are 2'-O-methylated

Tomoya Ohara et al. Nat Struct Mol Biol.

Abstract

Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs tested are fully modified by 2'-O-methylation at their 3' termini. This observation may provide a clue to the biogenesis and function of piRNAs in spermatogenesis.

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  • A Marked End
    X Chen. Nat Struct Mol Biol 14 (4), 259-60. PMID 17410089.
    microRNAs (miRNAs) and small interfering RNAs from plants are 2′-O-methylated at their 3′ termini. Although miRNAs from animals are not methylated, two studies sho …

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