Mouse Piwi-interacting RNAs Are 2'-O-methylated at Their 3' Termini

Nat Struct Mol Biol. 2007 Apr;14(4):347-8. doi: 10.1038/nsmb1218. Epub 2007 Mar 25.

Abstract

Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Argonaute Proteins
  • Male
  • Methylation
  • Mice
  • Phosphates / metabolism
  • Proteins / metabolism*
  • RNA / chemistry*
  • RNA / metabolism*
  • RNA Processing, Post-Transcriptional*
  • Testis / metabolism

Substances

  • Argonaute Proteins
  • Phosphates
  • Piwil1 protein, mouse
  • Proteins
  • RNA