Abstract
Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Argonaute Proteins
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Male
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Methylation
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Mice
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Phosphates / metabolism
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Proteins / metabolism*
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RNA / chemistry*
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RNA / metabolism*
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RNA Processing, Post-Transcriptional*
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Testis / metabolism
Substances
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Argonaute Proteins
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Phosphates
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Piwil1 protein, mouse
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Proteins
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RNA