Association between periodontal disease and acute coronary syndrome

Arq Bras Cardiol. 2007 Feb;88(2):185-90. doi: 10.1590/s0066-782x2007000200009.
[Article in English, Portuguese]


Objective: To evaluate the relationship between PD and ACS and the association of PD and periodontitis in ACS patients.

Methods: Fifty-eight ACS patients and 57 controls with no history of coronary artery disease (CAD) were included in the study.

Variables: arterial hypertension, diabetes, dyslipidemia, obesity, history of CAD, cigarette smoking, and interleukin-1beta gene polymorphism.

Results: One hundred and fifteen subjects were enrolled in the study. In the ACS group, 58 patients were evaluated, 32 of whom (55.2%) were male and 26 (44.8%), female. In the control group, 57 subjects were evaluated, 32 (56.1%) of whom were male and 25 (43.9%), female. Periodontal disease was diagnosed in 26 (44.8%) ACS patients and 15 (26.6%) control patients (beta2 = 4.43, p = 0.04). In a logistic regression analysis, the odds ratio for association between PD and ACS was 1.8 (95% CI: 1.0-5.0); p = 0.24. The odds ratio for association of periodontitis with ACS was 4.5 (95% CI: 1.3-15.6); p = 0.019.

Conclusion: No independent association was found between PD and ACS. There was an independent association between periodontitis and ACS.

MeSH terms

  • Aged
  • Angina, Unstable / complications*
  • Case-Control Studies
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction / complications*
  • Periodontal Diseases / complications*
  • Periodontal Index
  • Risk Factors