Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved?

Kidney Int. 2007 Apr;71(7):600-1. doi: 10.1038/sj.ki.5002126.

Abstract

The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures.

Publication types

  • Comment
  • Review

MeSH terms

  • Antibodies / immunology*
  • Autoantibodies / immunology*
  • DNA / immunology*
  • Humans

Substances

  • Antibodies
  • Autoantibodies
  • antiglomerular basement membrane antibody
  • DNA