Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans

Diabetologia. 2007 Jun;50(6):1156-60. doi: 10.1007/s00125-007-0651-y. Epub 2007 Mar 27.


Aims/hypothesis: Intra-abdominal fat (IAF) is an important risk factor for CHD and type 2 diabetes, and in cross-sectional studies is associated with the metabolic syndrome (MetS). Our aim was to determine whether IAF accumulation predicts the future development of MetS in non-diabetic Japanese-Americans.

Subjects and methods: We conducted a prospective study of 457 Japanese-American men and women (mean+/-SD: age 51.5 +/- 12.0 years, BMI 23.9 +/- 3.1 kg/m(2)) without diabetes or MetS at baseline. Of these, 408 completed a 5-year follow-up and 366 completed a 10-year follow-up. BMI, waist circumference, IAF and subcutaneous fat (SCF) areas by computed tomography, blood pressure, fasting plasma glucose, insulin, triacylglycerol and HDL-cholesterol were measured at baseline and at 5- and 10-year follow-up. MetS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria.

Results: Incidence of MetS was 15.3% at 5 years and 17.8% at 10 years. A change of 1 SD in IAF area was associated with a 2.1-fold increase in the odds of MetS at 10 years (odds ratio = 2.08, 95% CI 1.41-3.07) after adjusting for age, sex, baseline IAF and the presence of each individual MetS criteria at baseline. This association was independent of changes in fasting insulin and SCF areas.

Conclusions/interpretation: We conclude that IAF accumulation over time independently predicts the development of MetS and thus may play an important role in the development of MetS in Japanese-Americans.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Abdomen*
  • Adipose Tissue / anatomy & histology*
  • Asian Americans
  • Body Mass Index
  • Body Size
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Sex Characteristics
  • Washington / epidemiology