How to extract the weak photoacoustic signals from the collected signals with high noise is the key to photoacoustic signal processing. We have developed a modified filtered backprojection algorithm based on combination wavelet for high antinoise photoacoustic tomography. A Q-switched-Nd: yttrium-aluminum-garnet laser operating at 532 nm is used as light source. The laser has a pulse width of 7 ns and a repetition frequency of 20 Hz. A needle polyvinylidene fluoride hydrophone with diameter of 1 mm is used to capture photoacoustic signals. The modified algorithm is successfully applied to imaging vascular network of a chick embryo chorioallantoic membrane in situ and brain structure of a rat brain in vivo, respectively. In the reconstructed images, almost all of the capillary vessels and the vascular ramifications of the chick embryo chorioallantoic membrane are accurately resolved, and the detailed brain structures of the rat brain organization are clearly identified with the skull and scalp intact. The experimental results demonstrate that the modified algorithm has much higher antinoise capacity, and can greatly improve the reconstruction image quality. The spatial resolution of the reconstructed images can reach 204 microm. The modified filtered back-projection algorithm based on the combination wavelet has the potential in the practical high-noise signal processing for deeply penetrating photoacoustic tomography.