Advances in understanding ventromedial prefrontal function: the accountant joins the executive

Neurology. 2007 Mar 27;68(13):991-5. doi: 10.1212/01.wnl.0000257835.46290.57.


Studies of the brain basis of decision-making and economic behavior are providing a new perspective on the organization and functions of human prefrontal cortex. This line of inquiry has focused particularly on the ventral and medial portions of prefrontal cortex, arguably the most enigmatic regions of the "enigmatic frontal lobes." This review highlights recent advances in the cognitive neuroscience of decision making and neuroeconomics and discusses how these findings can inform clinical thinking about frontal lobe dysfunction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Avoidance Learning / physiology
  • Cognition / physiology*
  • Decision Making / physiology*
  • Emotions / physiology
  • Humans
  • Judgment / physiology*
  • Motivation*
  • Neurocognitive Disorders / etiology
  • Neurocognitive Disorders / physiopathology
  • Prefrontal Cortex / anatomy & histology
  • Prefrontal Cortex / physiology*
  • Risk-Taking