Short-term clinical exposure evaluation of a second-generation electrically heated cigarette smoking system

J Clin Pharmacol. 2007 Apr;47(4):518-30. doi: 10.1177/0091270006297686.

Abstract

This randomized, controlled, forced-switching, open-label, parallel-group study in 100 adult male and female smokers of conventional cigarettes evaluated 8 biomarkers of tobacco smoke exposure. After baseline exposure determinations, adult smokers were switched to a second-generation electrically heated cigarette smoking system (EHCSS) for 8 days in a clinical setting. After 8 days of smoking the EHCSS biomarkers of exposure decreased by 43% to 85% compared to baseline. After correction for residual effects (carryover effects due to long elimination half-life and non-tobacco-confounding sources of exposure), reductions in exposure ranged from 59% to 97%. Results from this short-term clinical exposure study indicate that switching from a conventional cigarette to a second-generation electrically heated cigarette smoking system substantially reduced the exposure to several measured potentially harmful constituents of tobacco smoke.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / urine
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nicotine / urine
  • Smoking / metabolism*
  • Smoking / urine
  • Tobacco Smoke Pollution / adverse effects
  • Tobacco Smoke Pollution / analysis*

Substances

  • Biomarkers
  • Tobacco Smoke Pollution
  • Nicotine