Review
doi: 10.1210/me.2007-0065.
Epub 2007 Mar 27.
The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity
Affiliations
- PMID: 17389748
- DOI: 10.1210/me.2007-0065
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Review
The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity
Mol Endocrinol.
2007 Jun.
Abstract
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
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