Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents

Nat Prod Rep. 2007 Apr;24(2):327-57. doi: 10.1039/b515619j. Epub 2007 Mar 8.

Abstract

This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Biological Products* / chemistry
  • Biological Products* / isolation & purification
  • Biological Products* / pharmacology
  • Humans
  • Microtubules / drug effects*
  • Molecular Structure
  • Paclitaxel / chemistry
  • Paclitaxel / isolation & purification
  • Paclitaxel / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Biological Products
  • Paclitaxel