Bromoalterochromides A and A', Unprecedented Chromopeptides From a Marine Pseudoalteromonas Maricaloris Strain KMM 636T

J Antibiot (Tokyo). 2007 Jan;60(1):36-42. doi: 10.1038/ja.2007.5.

Abstract

The marine strain Pseudoalteromonas maricaloris KMM 636T was found to produce an inseparable mixture of two brominated yellow main pigments, bromoalterochromide A and A', in a ratio of 3: 1. Both pigments are Thr-Val-Asn-Asn-X pentapeptide lactones, where the amino group of Thr is acylated with 9-(3-bromo-4-hydroxyphenyl)-nona-2,4,6,8-tetraenoic acid, and X is aIle and Leu, respectively. They possess cytotoxic effects on developing eggs of the sea urchin Strongylocentrotus intermedius, but no antibiotic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacteria / drug effects
  • Bromine / analysis*
  • Depsipeptides / biosynthesis
  • Depsipeptides / chemistry
  • Depsipeptides / pharmacology*
  • Molecular Structure
  • Ovum / drug effects
  • Pigments, Biological / biosynthesis
  • Pigments, Biological / chemistry
  • Pigments, Biological / isolation & purification
  • Pigments, Biological / pharmacology*
  • Pseudoalteromonas / chemistry*
  • Strongylocentrotus / drug effects

Substances

  • Depsipeptides
  • Pigments, Biological
  • bromoalterochromide A
  • bromoalterochromide A'
  • Bromine