CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment

Br J Clin Pharmacol. 2007 Sep;64(3):391-5. doi: 10.1111/j.1365-2125.2007.02884.x. Epub 2007 Mar 28.

Abstract

Aims: To determine the prevalence of the novel CYP2B6 functional polymorphism 983T>C in Papua New Guinea where HIV/AIDS poses a significant health problem.

Method: We genotyped Papua New Guineans (PNG, n = 174), West Africans (WA, n = 170), and North Americans (NA, n = 361).

Results: The polymorphism was absent in PNG, while its overall frequency was 4.7% in WA. Among NA, the polymorphism was present in African-Americans (7.5%) and Hispanic-Americans (1.1%) but not in Caucasian-Americans and Asian-Americans. Haplotype analysis indicated that 983T>C was present alone as the CYP2B6*18 allele in WA and African-Americans.

Conclusions: Significant interethnic differences occur at the CYP2B6 locus, which may influence treatment outcomes with efavirenz.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / genetics
  • African Americans
  • Alkynes
  • Alleles
  • Anti-HIV Agents / therapeutic use
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Benzoxazines / therapeutic use
  • Cyclopropanes
  • Cytochrome P-450 CYP2B6
  • Genotype
  • HIV Infections / drug therapy
  • Haplotypes
  • Humans
  • Oxidoreductases, N-Demethylating / genetics*
  • Papua New Guinea / ethnology
  • Polymorphism, Single Nucleotide*
  • Population Groups*
  • United States / ethnology

Substances

  • Alkynes
  • Anti-HIV Agents
  • Benzoxazines
  • Cyclopropanes
  • Aryl Hydrocarbon Hydroxylases
  • CYP2B6 protein, human
  • Cytochrome P-450 CYP2B6
  • Oxidoreductases, N-Demethylating
  • efavirenz