Fisher/Gullain-Barré overlap syndrome in advanced AIDS

J Neurol Sci. 2007 Jul 15;258(1-2):148-50. doi: 10.1016/j.jns.2007.02.029. Epub 2007 Mar 27.


Human immunodeficiency virus-associated Guillain-Barré syndrome typically occurs early in HIV infection before AIDS develops. We report a 56-year-old male AIDS patient, who developed overlapping Fisher/Guillain-Barré syndrome despite markedly decreased CD4 cell counts. Serum anti-GQ1b IgG antibody was positive. His condition improved rapidly after immunoglobulin treatment. This indicates that Fisher/Guillain-Barré syndrome may occur even in severely immunosuppressed patients and that anti-ganglioside antibody production is possibly mediated by a T cell-independent process.

Publication types

  • Case Reports

MeSH terms

  • Guillain-Barre Syndrome / etiology*
  • Guillain-Barre Syndrome / virology
  • HIV Infections / complications*
  • Humans
  • Male
  • Middle Aged
  • Miller Fisher Syndrome / etiology*
  • Miller Fisher Syndrome / virology