Abstract
Thirteen outpatients with chronic but stable schizophrenia received donepezil and placebo augmentation of their maintenance antipsychotic medication regimen. Each subject received in a randomized, counterbalanced order 1) donepezil 5 mg for 6 weeks then donepezil 10 mg for six weeks and 2) placebo donepezil for 12 weeks. Serial ratings of the Positive and Negative Symptom Scale (PANSS) [Kay, S.R., Fiszbein, A., Opler, L.A., 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13(2): 261-276] were performed by a trained rater blind to the donepezil order and condition: at baseline, 12 weeks and 24 weeks. On donepezil as compared to baseline or placebo, there was a significant improvement in PANSS negative scores (p=.018, n=13). These results are discussed with respect to other studies using cholinesterase inhibitors as an augmentation strategy in schizophrenia.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antipsychotic Agents / administration & dosage*
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Antipsychotic Agents / adverse effects
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Benzodiazepines / administration & dosage
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Benzodiazepines / adverse effects
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Cholinesterase Inhibitors / administration & dosage*
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Cholinesterase Inhibitors / adverse effects
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Clozapine / administration & dosage
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Clozapine / adverse effects
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Cross-Over Studies
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Donepezil
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Double-Blind Method
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Drug Therapy, Combination
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Female
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Humans
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Indans / administration & dosage*
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Indans / adverse effects
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Male
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Middle Aged
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Nootropic Agents / administration & dosage*
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Nootropic Agents / adverse effects
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Olanzapine
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Piperidines / administration & dosage*
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Piperidines / adverse effects
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Psychiatric Status Rating Scales
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Psychotic Disorders / diagnosis
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology
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Risperidone / administration & dosage
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Risperidone / adverse effects
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Schizophrenia / diagnosis
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*
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Treatment Outcome
Substances
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Antipsychotic Agents
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Cholinesterase Inhibitors
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Indans
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Nootropic Agents
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Piperidines
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Benzodiazepines
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Donepezil
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Clozapine
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Risperidone
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Olanzapine