Abstract
Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cannabinoid Receptor Modulators / antagonists & inhibitors
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Cannabinoid Receptor Modulators / physiology*
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Dose-Response Relationship, Radiation
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Electric Stimulation / methods
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Endocannabinoids*
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Excitatory Postsynaptic Potentials / radiation effects
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Hippocampus / cytology
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In Vitro Techniques
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Inhibitory Postsynaptic Potentials / drug effects
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Inhibitory Postsynaptic Potentials / physiology
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Inhibitory Postsynaptic Potentials / radiation effects
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Neural Inhibition
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Neuronal Plasticity / drug effects
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Neuronal Plasticity / physiology*
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Neurons / physiology*
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Patch-Clamp Techniques / methods
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Piperidines / pharmacology
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Pyrazoles / pharmacology
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Pyridines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Rimonabant
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Synapses / physiology*
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Time Factors
Substances
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Excitatory Amino Acid Antagonists
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Piperidines
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Pyrazoles
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Pyridines
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6-methyl-2-(phenylethynyl)pyridine
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Rimonabant