Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer

Med Sci Monit. 2007 Apr;13(4):CR195-200.

Abstract

Background: Lung cancer is the leading cause of cancer death in both developed and developing countries. The aim of the present study was to compare serum levels of alpha1-acid glycoprotein, ceruloplasmin, transferrin, ferritin, and albumin with tumor stage, distant metastasis, lymphadenopa thy, and patient performance status in patients with non-small-cell lung cancer and those with small-cell lung cancer.

Material/methods: The study was carried out in 46 patients with primary lung cancer (39 men and 7 women) and 34 healthy subjects as the control group.

Results: Serum ceruloplasmin and ferritin levels were higher and transferrin and albumin levels were lower both in non-small-cell and small-cell lung cancer patients than in controls. The levels of alpha1-acid glycoprotein and ferritin associated with both performance status and lymph node metastasis.

Conclusions: Measurement of alpha1-acid glycoprotein and ferritin levels could be a useful prognostic factor in addition to performance status in patient with primary lung cancer.

Publication types

  • Comparative Study

MeSH terms

  • Acute-Phase Proteins / analysis*
  • Adult
  • Aged
  • Ceruloplasmin / analysis
  • Female
  • Ferritins / blood
  • Humans
  • Lung Neoplasms / blood*
  • Lung Neoplasms / complications
  • Lymphatic Diseases / blood
  • Lymphatic Diseases / etiology
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Orosomucoid / analysis
  • Serum Albumin / analysis
  • Statistics, Nonparametric
  • Transferrin / analysis

Substances

  • Acute-Phase Proteins
  • Orosomucoid
  • Serum Albumin
  • Transferrin
  • Ferritins
  • Ceruloplasmin