The novel MGC13096 protein is correlated with proliferation

Cell Biochem Funct. 2008 Mar-Apr;26(2):141-5. doi: 10.1002/cbf.1410.

Abstract

We report a functional characterisation of the novel protein MGC13096. MGC13096 over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of MGC13096 severely delays cell cycle progression at S phase. Transcription factors such as activator protein-1 (AP-1), cAMP response element binding protein (CREB), nuclear factor of activated T cells (NFAT), NF-kappaB, signal transducer and activator of transcription 1 (STAT1) took part in the process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / physiology
  • Carrier Proteins
  • Cell Proliferation*
  • Cells, Cultured
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Gene Expression Profiling
  • Humans
  • Molecular Sequence Data
  • Molecular Weight
  • NF-kappa B / metabolism
  • NFATC Transcription Factors / metabolism
  • RNA, Messenger / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • S Phase / physiology
  • STAT1 Transcription Factor / metabolism
  • Time Factors
  • Transcription Factor AP-1 / metabolism

Substances

  • Apoptosis Regulatory Proteins
  • Carrier Proteins
  • Cyclic AMP Response Element-Binding Protein
  • NF-kappa B
  • NFATC Transcription Factors
  • PDCD2L protein, human
  • RNA, Messenger
  • STAT1 Transcription Factor
  • Transcription Factor AP-1

Associated data

  • GENBANK/NM032346
  • GENBANK/NP115722