Abstract
We report a functional characterisation of the novel protein MGC13096. MGC13096 over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of MGC13096 severely delays cell cycle progression at S phase. Transcription factors such as activator protein-1 (AP-1), cAMP response element binding protein (CREB), nuclear factor of activated T cells (NFAT), NF-kappaB, signal transducer and activator of transcription 1 (STAT1) took part in the process.
Copyright 2007 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis Regulatory Proteins / genetics
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Apoptosis Regulatory Proteins / physiology
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Carrier Proteins
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Cell Proliferation*
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Cells, Cultured
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Cyclic AMP Response Element-Binding Protein / metabolism
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Gene Expression Profiling
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Humans
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Molecular Sequence Data
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Molecular Weight
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NF-kappa B / metabolism
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NFATC Transcription Factors / metabolism
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RNA, Messenger / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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S Phase / physiology
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STAT1 Transcription Factor / metabolism
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Time Factors
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Transcription Factor AP-1 / metabolism
Substances
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Apoptosis Regulatory Proteins
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Carrier Proteins
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Cyclic AMP Response Element-Binding Protein
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NF-kappa B
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NFATC Transcription Factors
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PDCD2L protein, human
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RNA, Messenger
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STAT1 Transcription Factor
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Transcription Factor AP-1
Associated data
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GENBANK/NM032346
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GENBANK/NP115722