Germinal centres in T-cell-dependent antibody responses

Immunol Today. 1992 Jan;13(1):17-21. doi: 10.1016/0167-5699(92)90199-H.


For more than a century follicles have been recognized as a site of intense cell proliferation and cell death. At last the significance of this activity is beginning to emerge: antigen-driven B-cell proliferation, somatic mutation, positive and negative selection, and memory and plasma cell development all appear to take place within the follicle.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Formation
  • B-Lymphocytes / immunology*
  • Humans
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • Mutation
  • Selection, Genetic
  • T-Lymphocytes / immunology*