Abstract
[reaction: see text] The in situ preparation of a sulfonium ylide reagent achieved the highly diastereoselective epoxidation of isatins, so that a new and straightforward access to biologically significant spiro-epoxyoxindoles is provided. The first investigations of an asymmetric version are reported with enantiopure sulfides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Epoxy Compounds / chemical synthesis*
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Epoxy Compounds / chemistry
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Indoles / chemical synthesis
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Indoles / chemistry*
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Molecular Structure
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Oxindoles
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stereoisomerism
Substances
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Epoxy Compounds
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Indoles
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Oxindoles
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Spiro Compounds
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2-oxindole
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N-methylisatin