Motor evoked potential: a reliable and objective measure to document the functional consequences of multiple sclerosis? Relation to disability and MRI

Clin Neurophysiol. 2007 Jun;118(6):1332-40. doi: 10.1016/j.clinph.2007.02.018. Epub 2007 Mar 29.


Objective: In an attempt to analyze whether MEP can serve as a valid measure for evaluating neurological dysfunction in multiple sclerosis (MS), we related MEP to clinical and MRI measures.

Methods: Transcranial magnetic stimulation was applied in 52 MS patients to determine the central motor conduction time (CMCT) to the extremities. We calculated Z-scores for each CMCT (Zcmct) corrected for height. All patients underwent two clinical measurements and a MRI scan, of which T1 and T2 brain lesion volumes, brain volume, spinal cord volume and the number of T2 spinal cord lesions were derived.

Results: The clinical measurements correlated significantly with various Zcmct (Spearman correlation coefficients ranged from 0.29 to 0.53; p<0.05). The number of spinal cord lesions, brain T1 and T2 lesion volume and spinal cord volume correlated with various Zcmct (r=0.31-0.53; p<0.05). Linear regression analysis revealed that the clinical measurements were explained by Zcmct left leg and T1 lesion volume (adjusted R(2)=0.38). For one clinical measurement the number of spinal cord lesions was also included (adjusted R(2)=0.43).

Conclusion: We found a relation between MEP, brain and spinal cord MRI measures, and two clinical measures. Moreover, a model for explaining disability in MS revealed that MEP measures provide information in addition to MRI measures.

Significance: This study suggests that MEP is a measure that might adequately reflect pathology and neurological dysfunction in MS.

MeSH terms

  • Adult
  • Aged
  • Brain Mapping
  • Disability Evaluation*
  • Electroencephalography
  • Electromyography
  • Evoked Potentials, Motor / physiology*
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Models, Statistical
  • Multiple Sclerosis / pathology*
  • Multiple Sclerosis / physiopathology*
  • Reaction Time
  • Severity of Illness Index
  • Spinal Cord / physiology
  • Spinal Cord / physiopathology
  • Transcranial Magnetic Stimulation / methods