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. 2007 Apr 1;99(7):903-5.
doi: 10.1016/j.amjcard.2006.11.036. Epub 2007 Feb 8.

Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease


Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease

José L Pérez-Castrillón et al. Am J Cardiol. .


Vitamin D deficiency is a risk factor for osteoporosis and other chronic diseases, including type 1 diabetes, hypertension, metabolic syndrome, and ischemic heart disease. Cholesterol and vitamin D share the 7-dehydrocholesterol metabolic pathway. This study evaluated the possible effect of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Eighty-three patients (52 men and 31 women) with an acute coronary syndrome (75 with acute myocardial infarction and 8 with unstable angina) were included. After diagnosis, patients received atorvastatin as secondary prevention. Serum vitamin D was measured by high-performance liquid chromatography at baseline and at 12 months. Atorvastatin treatment produced a statistically significant decrease in cholesterol and triglyceride levels and an increase in vitamin D levels (41+/-19 vs 47+/-19 nmol/L, p=0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion, atorvastatin increases vitamin D levels. This increase could explain some of the beneficial effects of atorvastatin at the cardiovascular level that are unrelated to cholesterol levels.

Comment in

  • Statins and vitamin D.
    Aloia JF, Li-Ng M, Pollack S. Aloia JF, et al. Am J Cardiol. 2007 Oct 15;100(8):1329. doi: 10.1016/j.amjcard.2007.05.024. Epub 2007 Jul 5. Am J Cardiol. 2007. PMID: 17920383 Free PMC article. Clinical Trial. No abstract available.

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