Emulsification of Densiron-68 used in inferior retinal detachment surgery

Eye (Lond). 2008 Jan;22(1):152-7. doi: 10.1038/sj.eye.6702784. Epub 2007 Mar 30.


Purpose: To report the clinical features of eight patients presenting with emulsification of the heavier than water vitreous substitute, Densiron-68.

Methods: Two patients underwent primary inferior retinal detachment (RD) surgery, two patients underwent giant retinal tear repair, three patients had repair of inferior RD complicated by proliferative vitreoretinopathy and one patient had inferior RD surgery following repair of a scleral rupture. All patients had insertion of Densiron-68.

Results: Significant emulsification of Densiron-68 was seen within 12 weeks of surgery in eight cases out of a total of 40 patients receiving Densiron-68.

Conclusion: Despite adequate Densiron fills, emulsification necessitated its removal. Emulsified Densiron may have contributed to significant intraocular inflammation, epiretinal membrane formation and cystoid macular oedema. Without removal, prolonged presence of emulsified Densiron may lead to keratopathy, secondary glaucoma and retinal toxicity secondary to partitioning of perfluorohexyloctane. This has potentially significant implications on the indications for Densiron-68 use and warrants consideration before deciding on the optimal surgical intervention for inferior RDs.

MeSH terms

  • Adult
  • Aged
  • Emulsions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retinal Detachment / surgery*
  • Silicone Oils / adverse effects*
  • Silicone Oils / chemistry
  • Visual Acuity / physiology


  • Emulsions
  • Silicone Oils
  • densiron