Cycloplegic effect of 0.5% tropicamide and 0.5% phenylephrine mixed eye drops: objective assessment in Japanese schoolchildren with myopia

Jpn J Ophthalmol. 2007 Mar-Apr;51(2):111-5. doi: 10.1007/s10384-006-0400-7. Epub 2007 Apr 6.


Purpose: To evaluate the cycloplegic effect of mixed eye drops containing 0.5% tropicamide and 0.5% phenylephrine in myopic children, and to determine whether their efficacy was associated with their clinical characteristics.

Methods: Eighty-one myopic children (age, mean +/- SD, 11.0 +/- 1.5 years; mean spherical equivalent refractive error, -4.27 +/- 1.41 D; range, -1.57 to -8.66 D) were recruited. One drop of Mydrin-P was administered to each eye twice, with an interval of 5 min between. Twenty-five minutes after the second drop, accommodative responses were measured with an open-view autorefractometer, while the subject was encouraged to accommodate by binocularly looking at a Maltese cross located at a distance of 33 cm. The difference between the refractive reading and that obtained with a Maltese cross at 500 cm was regarded as residual accommodation (RA). The repeatability of this measurement was also evaluated.

Results: The mean RA was 0.21 +/- 0.29 D (range, -0.31 to 0.99 D). There was no association in RA between the right and left eyes, between RA and age, or between RA and sex, but RA was weakly correlated with refractive error (r = 0.274, P = 0.019). The intersubject difference found in RA can be explained mostly by the extent of repeatability (+/-0.71 D).

Conclusion: The insignificant magnitude of RA indicated that the mixed eye drop is an acceptable and useful cycloplegic agent in Japanese schoolchildren with a wide range of myopic refractive errors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accommodation, Ocular / drug effects*
  • Adolescent
  • Asians
  • Child
  • Ciliary Body / drug effects
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Mydriatics / administration & dosage*
  • Myopia / complications*
  • Myopia / ethnology
  • Ophthalmic Solutions / administration & dosage*
  • Phenylephrine / administration & dosage*
  • Pupil / drug effects
  • Refraction, Ocular
  • Tropicamide / administration & dosage*


  • Mydriatics
  • Ophthalmic Solutions
  • Phenylephrine
  • Tropicamide