A guide to murine coagulation factor structure, function, assays, and genetic alterations

J Thromb Haemost. 2007 Apr;5(4):670-9. doi: 10.1111/j.1538-7836.2007.02408.x.


Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Coagulation
  • Disease Models, Animal*
  • Fibrinogen / genetics
  • Hemostasis / genetics
  • Humans
  • Mice
  • Models, Biological
  • Models, Genetic
  • Partial Thromboplastin Time
  • Prothrombin Time
  • Thrombosis / genetics


  • Fibrinogen