We have developed computer-aided diagnosis (CAD) schemes for the detection of lung nodules, interstitial lung diseases, interval changes, and asymmetric opacities, and also for the differential diagnosis of lung nodules and interstitial lung diseases on chest radiographs. Observer performance studies indicate clearly that radiologists' diagnostic accuracy was improved significantly when radiologists used a computer output in their interpretations of chest radiographs. In addition, the automated recognition methods for the patient and the projection view by use of chest radiographs were useful for integrating the chest CAD schemes into the picture-archiving and communication system (PACS).