Treatment of glabellar frown lines with C. botulinum-A exotoxin

J Dermatol Surg Oncol. 1992 Jan;18(1):17-21. doi: 10.1111/j.1524-4725.1992.tb03295.x.


Eighteen patients with glabellar frown lines were treated with C. botulinum-A exotoxin. Sixteen of the 17 patients followed showed improvement for periods ranging from 3 months to 11 months. Side-effects were minimal and transient. Because C. botulinum-A exotoxin therapy of glabellar frown lines treats the underlying cause of these lines, it is more effective than soft tissue augmentation although this improvement is temporary. Treatment with C. botulinum-A exotoxin is a simple, safe procedure.

MeSH terms

  • Adult
  • Botulinum Toxins / administration & dosage*
  • Botulinum Toxins / adverse effects
  • Facial Expression
  • Facial Muscles
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Skin Aging*


  • Botulinum Toxins