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Meta-Analysis
. 2007 Apr 10;96(7):1127-34.
doi: 10.1038/sj.bjc.6603649.

Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review

S A Raza  1 , G M Clifford, S Franceschi
Affiliations
Free PMC article
Meta-Analysis

Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review

S A Raza et al. Br J Cancer. .
Free PMC article

Abstract

We combined information published worldwide on the seroprevalence of hepatitis B surface antigen (HbsAg) and antibodies against hepatitis C virus (anti-HCV) in 27 881 hepatocellular carcinomas (HCCs) from 90 studies. A predominance of HBsAg was found in HCCs from most Asian, African and Latin American countries, but anti-HCV predominated in Japan, Pakistan, Mongolia and Egypt. Anti-HCV was found more often than HBsAg in Europe and the United States.

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Figures

Figure 1
Figure 1
Seroprevalence and corresponding 95% confidence intervals of HBsAg, anti-HCV, both and negative in patients with HCC in Asia. *Indonesia, Myanmar, Iran, Lebanon and Saudi Arabia.
Figure 2
Figure 2
Seroprevalence and corresponding 95% confidence intervals of HBsAg, anti-HCV, both and negative in patients with HCC in Europe. *Belgium and the United Kingdom.
Figure 3
Figure 3
Seroprevalence and corresponding 95% confidence intervals of HBsAg, anti-HCV, both and negative in patients with HCC in the Americas and Africa. *Peru and Mexico; †Sudan, Nigeria, Niger, Senegal and Somalia.
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