Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 76, 679-99

DNA Replication and Transcription in Mammalian Mitochondria

Affiliations
Review

DNA Replication and Transcription in Mammalian Mitochondria

Maria Falkenberg et al. Annu Rev Biochem.

Abstract

The mitochondrion was originally a free-living prokaryotic organism, which explains the presence of a compact mammalian mitochondrial DNA (mtDNA) in contemporary mammalian cells. The genome encodes for key subunits of the electron transport chain and RNA components needed for mitochondrial translation. Nuclear genes encode the enzyme systems responsible for mtDNA replication and transcription. Several of the key components of these systems are related to proteins replicating and transcribing DNA in bacteriophages. This observation has led to the proposition that some genes required for DNA replication and transcription were acquired together from a phage early in the evolution of the eukaryotic cell, already at the time of the mitochondrial endosymbiosis. Recent years have seen a rapid development in our molecular understanding of these machineries, but many aspects still remain unknown.

Similar articles

See all similar articles

Cited by 223 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback