Pulmonary vaccine delivery

Expert Rev Vaccines. 2007 Apr;6(2):213-26. doi: 10.1586/14760584.6.2.213.

Abstract

This review will discuss developments in the field of pulmonary vaccine delivery. The possibilities of adopting aerosol-generation technology and specific pharmaceutical formulations for the purpose of pulmonary immunization are described. Aerosol-generation systems might offer advantages with respect to vaccine stability and antigenicity. Adjuvants and their inclusion in vaccine-delivery systems are described. Other formulation components, such as surfactants, particulate systems and dispersion of the aerosols are detailed in this paper. The noninvasive, relatively safe and low-cost nature of pulmonary delivery may provide great benefits to the public health vaccination campaign.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Administration, Inhalation
  • Aerosols
  • Animals
  • Chemistry, Pharmaceutical
  • Drug Carriers / chemistry*
  • Drug Compounding
  • Drug Delivery Systems* / instrumentation
  • Drug Stability
  • Gene Transfer Techniques
  • Humans
  • Immunity, Mucosal
  • Metered Dose Inhalers
  • Nebulizers and Vaporizers
  • Particle Size
  • Powders
  • Surface-Active Agents / chemistry
  • Technology, Pharmaceutical
  • Vaccination / instrumentation
  • Vaccination / methods*
  • Vaccination / trends
  • Vaccines / administration & dosage*
  • Vaccines / chemistry*
  • Vaccines / genetics
  • Vaccines / immunology

Substances

  • Adjuvants, Immunologic
  • Aerosols
  • Drug Carriers
  • Powders
  • Surface-Active Agents
  • Vaccines