Paracentral rheumatoid corneal ulceration. Clinical features and cyclosporine therapy

Ophthalmology. 1992 Jan;99(1):80-8. doi: 10.1016/s0161-6420(92)32006-8.


Six patients with rheumatoid arthritis (eight eyes) presented with small paracentral perforating corneal ulcers in otherwise quiet eyes. Initial management in five patients (seven eyes) consisted of systemic immunosuppression and therapeutic tissue adhesive with a bandage contact lens or tectonic keratoplasty. Ulceration recurred in all of these eyes, and recurrent ulcers treated with repeat tectonic keratoplasty or therapeutic tissue adhesive and a bandage contact lens all developed recurrent ulceration. The introduction of topical cyclosporine therapy in five eyes with recurrent corneal ulceration was associated with arrest of keratolysis and rapid re-epithelialization of the ulcer in all cases. One corneal ulcer was successfully treated initially with topical cyclosporine, tissue adhesive, and a bandage contact lens. In patients with rheumatoid arthritis and small paracentral corneal ulcerations or perforations, application of tissue adhesive and a bandage contact lens and introduction of topical cyclosporine may be the preferred initial treatment.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Antibodies, Monoclonal
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / pathology*
  • Arthritis, Rheumatoid / surgery
  • Contact Lenses
  • Cornea / immunology
  • Corneal Ulcer / drug therapy
  • Corneal Ulcer / immunology
  • Corneal Ulcer / pathology*
  • Corneal Ulcer / surgery
  • Cyclosporine / therapeutic use*
  • Female
  • HLA-DR Antigens / analysis
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulins / analysis
  • Keratoplasty, Penetrating
  • Lymphocytes / immunology
  • Male
  • Middle Aged
  • Recurrence
  • Tissue Adhesives
  • Visual Acuity


  • Antibodies, Monoclonal
  • HLA-DR Antigens
  • Immunoglobulins
  • Tissue Adhesives
  • Cyclosporine