Bridge to lung transplantation with the extracorporeal membrane ventilator Novalung in the veno-venous mode: the initial Hannover experience

ASAIO J. 2007 Mar-Apr;53(2):168-70. doi: 10.1097/MAT.0b013e31802deb46.


Conventional extracorporeal membrane oxygenation and mechanical ventilation have both been identified as significant risk factors for post-lung transplant mortality when applied as a bridge to lung transplantation. We have previously described the successful use of the extracorporeal membrane ventilator Novalung as a bridge to lung transplantation in patients with severe hypercapnia and respiratory acidosis. In this setting the Novalung was connected in the arterio-venous mode without support of a mechanical blood pump. However, in patients with predominant hypoxemia, this pumpless mode does not achieve sufficient blood oxygenation due to limited blood flow. Thus, such patients require pump-driven support. Here we describe our initial experience with the Novalung extracorporeal membrane ventilator, which was originally designed for pumpless carbon dioxide removal, as a bridge to lung transplantation in patients with ventilator-refractory hypoxemia in the veno-venous pump-driven mode.

MeSH terms

  • Adult
  • Cystic Fibrosis / complications
  • Equipment Design
  • Extracorporeal Membrane Oxygenation / instrumentation*
  • Extracorporeal Membrane Oxygenation / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Hypoxia / blood
  • Hypoxia / physiopathology
  • Lung Transplantation*
  • Radiography, Thoracic
  • Time Factors
  • Treatment Outcome
  • Ventilators, Mechanical*