Brain activation during human male ejaculation revisited

Neuroreport. 2007 Apr 16;18(6):553-7. doi: 10.1097/WNR.0b013e3280b10bfe.


In a prior [O]-H2O positron emission tomographic study we reported brain regions involved in human male ejaculation. Here, we used another, more recently acquired data set to evaluate the methodological approach of this previous study, and discovered that part of the reported activation pattern was not related to ejaculation. With a new analysis of these ejaculation data, we now demonstrate ejaculation-related activations in the deep cerebellar nuclei (dentate nucleus), anterior vermis, pons, and ventrolateral thalamus, and, most importantly, ejaculation-related deactivations throughout the prefrontal cortex. This revision offers a new and more accurate insight into the brain regions involved in human male ejaculation.

MeSH terms

  • Cerebellar Nuclei / diagnostic imaging
  • Cerebellar Nuclei / physiology*
  • Ejaculation / physiology*
  • Humans
  • Male
  • Orgasm / physiology*
  • Oxygen Radioisotopes
  • Pons / diagnostic imaging
  • Pons / physiology
  • Positron-Emission Tomography*
  • Prefrontal Cortex / diagnostic imaging
  • Prefrontal Cortex / physiology*
  • Ventral Thalamic Nuclei / diagnostic imaging
  • Ventral Thalamic Nuclei / physiology


  • Oxygen Radioisotopes