Epigenetics and microRNAs

Pediatr Res. 2007 May;61(5 Pt 2):17R-23R. doi: 10.1203/pdr.0b013e318045760e.


MicroRNAs (miRNAs) regulate protein-coding genes post transcriptionally in higher eukaryotes. Argonaute proteins are important in miRNA regulation and are also implicated in epigenetic mechanisms such as histone modifications and DNA methylation. Here, we review miRNA regulation and outline its connections to epigenetics.

Publication types

  • Review

MeSH terms

  • Animals
  • Epigenesis, Genetic*
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / chemistry
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Nucleic Acid Conformation
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism


  • MicroRNAs
  • RNA-Binding Proteins