Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine

M Yu Bobrov; A A Lyzhin; E L Andrianova; N M Gretskaya; G N Zinchenko; L E Frumkina; L G Khaspekov; V V Bezuglov

doi:10.1007/s10517-006-0383-x

Antioxidant and neuroprotective properties of N-docosahexaenoyl dopamine

Bull Exp Biol Med. 2006 Oct;142(4):425-7. doi: 10.1007/s10517-006-0383-x.

[Article in English, Russian]

Authors

M Yu Bobrov¹, A A Lyzhin, E L Andrianova, N M Gretskaya, G N Zinchenko, L E Frumkina, L G Khaspekov, V V Bezuglov

Affiliation

¹ Laboratory of Oxylipins, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.

PMID: 17415428
DOI: 10.1007/s10517-006-0383-x

Abstract

N-Docosahexaenoyl dopamine exhibited antioxidant activity in the test with a stable oxygen radical galvinoxyl. This compound produced a dose-dependent protective effect on cultured granular cells from rat cerebellum under conditions of oxidative stress. N-Docosahexaenoyl dopamine decelerated the development of symptoms of Parkinson's disease in mice receiving neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / pharmacology*
Cells, Cultured
Cerebellum / cytology
Cerebellum / drug effects
Cerebellum / physiology*
Dopamine / analogs & derivatives*
Dopamine / pharmacology
Dose-Response Relationship, Drug
Neurons / drug effects
Neurons / physiology
Neuroprotective Agents / pharmacology*
Oxidative Stress / drug effects
Parkinsonian Disorders / physiopathology
Rats

Substances

Antioxidants
N-docosahexaenoyl dopamine
Neuroprotective Agents
Dopamine