Effects of L-, D-, and DL-carnitine on Morphometric Parameters of Skeletal Muscle and Exercise Performance of Laboratory Animals Receiving Carnitine-Deficient Diet

Bull Exp Biol Med. 2006 Oct;142(4):458-60. doi: 10.1007/s10517-006-0391-x.
[Article in English, Russian]

Abstract

Serum concentration of L-carnitine, the mean thickness of the skeletal muscle fiber, and exercise performance in the forced swimming test decreased in rats receiving a carnitine-deficient diet. Treatment with L-carnitine compensated for carnitine deficiency, while racemate and D-stereoisomer did not increase its level. L-Carnitine, but not racemate and D-stereoisomer, promoted recovery of the skeletal muscle fiber thickness and exercise performance of rats.

MeSH terms

  • Animals
  • Carnitine / deficiency*
  • Carnitine / pharmacology*
  • Male
  • Models, Animal
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / physiology*
  • Physical Conditioning, Animal*
  • Rats
  • Stereoisomerism
  • Swimming

Substances

  • Carnitine