The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer

Hum Genet. 2007 Jun;121(5):635-7. doi: 10.1007/s00439-007-0361-z. Epub 2007 Apr 6.


The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cytoskeletal Proteins / genetics*
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Pancreatic Neoplasms / genetics*
  • Phosphoproteins / genetics*


  • Cytoskeletal Proteins
  • PALLD protein, human
  • Phosphoproteins